4-Methoxybenzenesulfonyl chloride → (+/-)-2-[2-(1-Benzyloxymethylpyrimidin-2,4-dione-3-yl)ethyl]-n-(4-methoxy-benzenesulfonyl)glycine allyl ester

Participants

Reaction Steps

In a similar manner to the procedures described in Example 1(2)-a and b, reactions were carried out using (±)-2-[2-(1-benzyloxymethylpyrimidin-2,4-dione-3-yl)ethyl]-N-(tert-butoxycarbonyl)glycine allyl ester, the product of (1) above, instead of (±)-N-(tert-butoxycarbonyl)-2-(2-phthalimidoethyl)glycine allyl ester and using 4-methoxybenzenesulfonyl chloride instead of 4-phenoxybenzenesulfonyl chloride to afford the desired compound (yield 93%) as a colorless oil.

Provenance & Evidence