HuagongsheHuagongshe Chemistry Print Report · For research reference only
(+/-)-N-(tert-butoxycarbonyl)homoserine allyl ester → (+/-)-2-[2-(1-Benzyloxymethylpyrimidin-2,4-dione-3-yl)ethyl]-n-(tert-butoxycarbonyl)glycine benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (+/-)-N-(tert-butoxycarbonyl)homoserine allyl ester | HCID 12042107 | — |
| Reactant | 1-((benzyloxy)methyl)pyrimidine-2,4(1H,3H)-dione | HCID 13016435 | — |
| Reactant | HCID 13970788 | HCID 13970788 | — |
| Product | Phthalimide | HCID 6809 | — |
| Product | (+/-)-2-[2-(1-Benzyloxymethylpyrimidin-2,4-dione-3-yl)ethyl]-n-(tert-butoxycarbonyl)glycine benzyl ester | HCID 18753538 | 74% |
Reaction Steps
In a similar manner to that described in Example 1(1), a reaction was carried out using (±)-N-(tert-butoxycarbonyl)homoserine benzyl ester, instead of (±)-N-(tert-butoxycarbonyl)homoserine allyl ester, and using 1-benzyloxymethylpyrimidine-2,4-dione, instead of phthalimide, to afford the desired compound (yield 74%) as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06673804B1 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-57ddea7013e6437d8c0b3eb718756c05 |
| Source note | uspto-grants-2004_01 |