HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-(Trifluoromethoxy)benzenesulphonyl chloride → (+/-)-2-(2-Phthalimidoethyl)-N-(4-trifluoromethoxybenzensulfonyl)glycine Benzyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-(Trifluoromethoxy)benzenesulphonyl chloride | HCID 523102 | — |
| Reactant | (+/-)-N-(tert-butoxycarbonyl)-2-(2-phthalimidoethyl)glycine benzyl ester | HCID 18753535 | — |
| Reactant | (+/-)-n-(Tert-butoxycarbonyl)-2-(phthalimidoethyl)glycine allyl ester | HCID 18753589 | — |
| Product | 4-Phenoxybenzene-1-sulfonyl chloride | HCID 2794756 | — |
| Product | (+/-)-2-(2-Phthalimidoethyl)-N-(4-trifluoromethoxybenzensulfonyl)glycine Benzyl Ester | HCID 18753638 | 52% |
Reaction Steps
In a similar manner to the procedures described in Example 1(2)-a and b, reactions were carried out using (±)-N-(tert-butoxycarbonyl)-2-(2-phthalimidoethyl)glycine benzyl ester, the product of Example 19(1), instead of (±)-N-(tert-butoxycarbonyl)-2-(2-phthalimidoethyl)glycine allyl ester, and using 4-trifluoromethoxybenzenesulfonyl chloride, instead of 4-phenoxybenzenesulfonyl chloride, to afford the desired compound (yield 52%) as a yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06673804B1 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-903b3acdbced432f926e223fa9773c5a |
| Source note | uspto-grants-2004_01 |