Methyl iodide → HCID 18753499, compound

Participants

Reaction Steps

After potassium carbonate (45.39 g, 328.4 mmol) was added to a solution of N-(4-phenoxybenzenesulfonyl)serinol (10.62 g, 32.84 mmol), the product of (1) above, in N,N-dimethylformamide (250 ml), methyl iodide (5.12 g, 36.12 mmol) was added dropwise to the mixture. After stirring it at room temperature for 2 hours, the same amount of methyl iodide was further added to this mixture and stirred for 1 hour. The solvent of the reaction mixture was evaporated under reduced pressure, ice-water was added to the resulting residue and this was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford the desired compound (8.32 g, yield 75%) as a white powder.

Provenance & Evidence