HCID 18753701, compound → HCID 18753689, compound

Participants

Reaction Steps

N-[4-(azidomethyl)cyclopent-2-enyl](t-butoxy)-carboxamide (10 g, 42 mmol) was dissolved in TFA reagent (9.25 mL TFA, 0.25 mL anisole, 0.25 mL triisopropylsilane and 0.25 mL water)and DCM (25 mL), and stirred for 30 min at rt. The reaction mixture was concentrated and the residue filtered through SCX column, eluted with ammonia (2 M solution in methanol), and evaporated to yield the title compound (4.6 g, 80%).: ESMS: 139 (M+1)+. 1H NMR (CDCl3): δ 1.40-1.55 (m, 1H), 2.45-2.60 (m, 1H), 2.90-3.00 (m, 1H), 3.40 (d, 2H), 4.104.20 (m, 1H), 5.90 (s, 2H).

Provenance & Evidence