Glycolaldehyde dimer → HCID 10503421, compound

HRID 1838482Notes

Reaction equation

HRID 1838482 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([CH2:8][CH:9]([CH3:11])[CH3:10])[CH:5]=[CH:4][C:3]=1[C:12]1[C:13]([S:18]([NH:21][C:22]2[O:26][N:25]=[C:24]([CH3:27])[C:23]=2[CH3:28])(=[O:20])=[O:19])=[CH:14][CH:15]=[CH:16][CH:17]=1.[CH2:29]1OC(O)C[O:31][CH:30]1O>C(Cl)Cl.C(OCC)(=O)C>[CH3:27][C:24]1[C:23]([CH3:28])=[C:22]([NH:21][S:18]([C:13]2[C:12]([C:3]3[CH:4]=[CH:5][C:6]([CH2:8][CH:9]([CH3:11])[CH3:10])=[CH:7][C:2]=3[NH:1][CH2:29][CH2:30][OH:31])=[CH:17][CH:16]=[CH:15][CH:14]=2)(=[O:20])=[O:19])[O:26][N:25]=1

Participants

4

Reactant 2

HCID 186078Glycolaldehyde dimerHCID 9908909153624-15-8

Product 1

HCID 10503421HCID 10503421, compound

Reagents, catalysts & solvents 1

HCID 21226138Dichloromethane ethylacetateSolvent

Procedure

The title compound was prepared from the compound of Example 32 and glycolaldehyde dimer as described for Example 58, with stirring at room temperature for 2 hours. Following workup, chromatography on silica gel with 4:1 methylene chloride/ethyl acetate afforded the title compound as a white solid, mp 45-53° C.

Sources & evidence

ORD record
ord-7f3eeab4dc4a4eb3b9278db53ce7adda
Source dataset
uspto-grants-2004_01
Patent number
US06673824B1

Reaction notes

Loading…