Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Venlafaxine | HCID 5656 | — |
| Reactant | 1-Dodecanethiol | HCID 8195 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Product | Desvenlafaxine | HCID 125017 | — |
Reaction Steps
Dodecanethiol (122 g), venlafaxine (111 g), and a methanolic solution of sodium methanolate (30%, 90 g) and PEG 400 are heated to 190° C. The methanol is distilled off and the solution is stirred for 2 hours at 190° C. Then the temperature is lowered, 2-propanol (450 g) is added and the pH is adjusted to 9.5 with aqueous HCl. The precipitate is collected by suction filtration, and the cake is washed with 2-propanol, toluene, 2-propanol and water. The wet O-desmethylvenlafaxine is dried in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06673838B2 |
|---|
| Source dataset | uspto-grants-2004_01 |
|---|
| ORD ID | ord-3a4051ac68c044ed89c11e973b3ec84d |
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| Source note | uspto-grants-2004_01 |
|---|
