HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 18753440, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | 1-(3-Hydroxypropyl)pyrrolidin-2-one | HCID 566744 | — |
| Reactant | 4-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-quinazolinol | HCID 135503852 | — |
| Product | HCID 18753440 | HCID 18753440 | 67% |
Reaction Steps
Using a method analogous to that in Example 47, 4-(4-bromo-2-fluoroanilino)-7-hydroxy-6-methoxyquinazoline (146 mg, 0. mmol) in methylene chloride (5 ml) was treated with 1-(3-hydroxypropyl)-2-pyrrolidinone (86 mg, 0.6 mmol), triphenylphosphine (314 mg, 1.2 mmol) and diethyl azodicarboxylate (209 mg, 1.2 mmol) and was purified and isolated to give 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(3-(2-oxopyrrolidin-1-yl)propoxy)quinazoline hydrochloride (140 mg, 67%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06673803B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-e4fadd4b9d114872a991ca1c627e3a67 |
| Source note | uspto-grants-2004_01 |