Sodium Cyanide → HCID 69556747, compound

HRID 1838648Notes

Reaction equation

HRID 1838648 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][C:6]([CH:7]=[O:8])=[CH:5][CH:4]=1.[S:13]([CH2:23][N+:24]#[C-:25])([C:16]1[CH:22]=[CH:21][C:19](C)=[CH:18][CH:17]=1)(=[O:15])=[O:14].[C-:26]#N.[Na+]>>[C:22]1([CH3:26])[C:16]([S:13]([C@@H:23]2[C@@H:7]([C:6]3[CH:9]=[CH:10][C:3]([C:2]([F:11])([F:12])[F:1])=[CH:4][CH:5]=3)[O:8][CH:25]=[N:24]2)(=[O:14])=[O:15])=[CH:17][CH:18]=[CH:19][CH:21]=1

Participants

4

Reactant 3

HCID 8929Sodium CyanideHCID 679964-(Trifluoromethyl)benzaldehydeHCID 161915Tosylmethyl isocyanide

Product 1

HCID 69556747HCID 69556747, compound

Procedure

In a manner analogous to Preparation 1, 4-(trifluoromethyl)-benzaldehyde (0.54 mL, 3.95 mmol), tosylmethylisocyanide (0.75 g, 3.84 mmol) and NaCN (0.02 g, 0.40 mmol) gave the desired compound as a tan solid. MS(ES+) m/z 411.2 (M+CH3CN+).

Sources & evidence

ORD record
ord-b32a176231374ea980650d53295a817e
Source dataset
uspto-grants-2004_01
Patent number
US06673941B2

Reaction notes

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