HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Cyanide → (4R *,5R*)-5-(4-chloro-3-trifluoromethyl-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 4-Chloro-3-(trifluoromethyl)benzaldehyde | HCID 118642 | — |
| Reactant | Tosylmethyl isocyanide | HCID 161915 | — |
| Product | (4R *,5R*)-5-(4-chloro-3-trifluoromethyl-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole | HCID 69556945 | — |
Reaction Steps
In a manner analogous to Preparation 1, 4-chloro-3-(trifluoromethyl)benzaldehyde (0.31 g, 1.47 mmol), tosylmethylisocyanide (0.27 g, 1.40 mmol) and NaCN (6.9 mg, 0.14 mmol) gave the desired compound as a tan solid. MS(ES+) m/z 404.5 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06673941B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-00720582f38548ef90c33263ef810705 |
| Source note | uspto-grants-2004_01 |