Thionyl Chloride → 2-Methyl-4,5-di(methylsulfonyl)benzoyl chloride

Participants

Reaction Steps

15 l of thionyl chloride are initially introduced at 40°, and 50 ml of DMF are added. 3.8 kg of 4,5-bismethanesulfonyl-2-methylbenzoic acid are slowly introduced with stirring, and the mixture is then stirred at the boiling point for 1 hour. After cooling, the excess SOCl2 is removed, and the residue is codistilled a number of times with 5 l of toluene, giving 4, 5-bismethanesulfonyl-2-methylbenzoyl chloride, which is reacted further as the crude product.

Provenance & Evidence