HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 57300936, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Lithium borohydride | HCID 4148881 | — |
| Reactant | (3S,4R,5R)-4-(4-allyloxy-phenyl)-3-[(2R)-2-hydroxy-3-methoxy-propoxy]-5-(4-methoxy-naphthalen-2-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester | HCID 57269223 | — |
| Catalyst | Palladium (II) acetate | HCID 4144353 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 57300936 | HCID 57300936 | — |
Reaction Steps
In analogy to the procedure described in example 11(c) the (3S,4R,5R)-4-(4-allyloxy-phenyl)-3-[(2R)-2-hydroxy-3-methoxy-propoxy]-5-(4-methoxy-naphthalen-2-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester was treated with palladium-II-acetate, triphenylphosphin and lithiumborohydride in tetrahydrofuran to yield the (3S,4R,5R)-3-[(2R)-2-hydroxy-3-methoxy-propoxy]-4-(4-hydroxy-phenyl)-5-(4-methoxy-naphthalen-2-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester as colorless oil; MS: 568 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06673931B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-f28c1cff114844a5b121c606c7101997 |
| Source note | uspto-grants-2004_01 |