Methyl iodide → (3-Fluoro-2-methoxyphenyl)methanol

HRID 1838749Notes

Reaction equation

[CH3:1]I.[F:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][OH:11])[C:5]=1[OH:12]>>[F:3][C:4]1[C:5]([O:12][CH3:1])=[C:6]([CH2:10][OH:11])[CH:7]=[CH:8][CH:9]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 187554072-Fluoro-6-(hydroxymethyl)phenol

Product 1

HCID 22505951(3-Fluoro-2-methoxyphenyl)methanol

Procedure

In an analogous manner to that described in (α) 2-fluoro-6-hydroxymethyl-phenol was alkylated with methyliodide to yield (3-fluoro-2-methoxy-phenyl)-methanol as a white solid; MS: 142 (M)+.

Sources & evidence

ORD record: ord-b4aa61e543984501b5de4de649b6f003
Source dataset: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06673931B2

Reaction notes

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