Acetophenone → 1-Phenylethanol

Participants

Reaction Conditions

Reaction Steps

For Example E15 according to the present invention, the above-described 300 ml autoclave provided with a metal basket fastened to the lid of the autoclave, as used in Example E6 to E12, was employed; in the present example, the metal basket was used for accommodating 9.2 g of the catalyst IC11 (wire mesh rings). In its center, the basket had a cylindrical opening for the shaft of the stirrer, so that the catalyst was supplied uniformly with liquid and gas. The autoclave was charged with 200 ml of cylcohexane and 8 g of acetophenone, closed and freed of air by pressurizing it twice to 100 bar with nitrogen. The autoclave was subsequently heated to 120° C. and 250 bar of hydrogen were injected. While injecting further hydrogen to replace that consumed, the mixture was stirred for a further 60 minutes at this temperature. A total of 1.59 liters of hydrogen were consumed. Analysis of the resulting product by gas chromatography indicated complete conversion of the acetophenone to form 1-phenylethanol (81%) and ethylbenzene (19%).

Provenance & Evidence