Morpholine → HCID 178516234, compound

HRID 1838777Notes

Reaction equation

HRID 1838777 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([OH:8])=[CH:4][CH:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>>[O:12]1[CH2:13][CH2:14][N:9]([C:2]2[N:7]=[N:6][C:5]([OH:8])=[CH:4][CH:3]=2)[CH2:10][CH2:11]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 178516069HCID 178516069, compound

Product 1

HCID 178516234HCID 178516234, compoundYield 74%

Procedure

6-Chloro-3-hydroxypyridazine (25.0 g, 0.191 mol) was dissolved in morpholine (120 mol), under reflux condition for 24 hours. After cooling, the deposited crystal was filtered, to give 6-morpholino-3-hydroxypyridazine in white crystal (25.8 g as a yield of 74%).

Workup

  1. temperatureunder reflux condition for 24 hours
  2. temperatureAfter cooling
  3. filtrationthe deposited crystal was filtered

Sources & evidence

ORD record
ord-76d7175eecc34b50bb81c615d383cea0
Source dataset
uspto-grants-2004_01
Patent number
US06676932B2

Reaction notes

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