反应详情

6-Chloro-3-hydroxypyridazine (25.0 g, 0.191 mol) was dissolved in morpholine (120 mol), under reflux condition for 24 hours. After cooling, the deposited crystal was filtered, to give 6-morpholino-3-hydroxypyridazine in white crystal (25.8 g as a yield of 74%).

1. temperatureunder reflux condition for 24 hours
2. temperatureAfter cooling
3. filtrationthe deposited crystal was filtered