Morpholine → 3,6-dimorpholinopyridazine

HRID 1838778Notes

Reaction equation

HRID 1838778 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5](Cl)=[CH:6][CH:7]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>>[O:12]1[CH2:13][CH2:14][N:9]([C:2]2[N:3]=[N:4][C:5]([N:9]3[CH2:14][CH2:13][O:12][CH2:11][CH2:10]3)=[CH:6][CH:7]=2)[CH2:10][CH2:11]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 673313,6-Dichloropyridazine

Product 1

HCID 64015573,6-dimorpholinopyridazineYield 80%

Procedure

3,6-Dichloropyridazine (25.0 g, 0.168 mol) was dissolved in morpholine (120 mol), for reflux condition for 24 hours. After cooling, the deposited crystal was filtered, to give 3,6-dimorpholinopyridazine in white crystal (33.7 g as a yield of 80%).

Workup

  1. temperaturefor reflux condition for 24 hours
  2. temperatureAfter cooling
  3. filtrationthe deposited crystal was filtered

Sources & evidence

ORD record
ord-18beba6e4c4d43e0b7398304e7938ac4
Source dataset
uspto-grants-2004_01
Patent number
US06676932B2

Reaction notes

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