Hydrochloric Acid → HCID 23448419, compound

Participants

Reaction Steps

A solution of 2-furoyl chloride (6.5 g; 50 mmol) was added dropwise at 0° C. to a solution of 8-chloro-1-octanol (6.6 g; 40 mmol) and pyridine (20 g; 253 mmol) and stirred at room temperature for 2 h. The resulting mixture was added to a mixture of 1N-hydrochloric acid and ice (200 ml) and extracted with ethyl acetate (3×80 ml). The combined organic layers were washed with saturated sodium chloride solution (2×80 ml), dried over magnesium sulphate and filtered. The organic solvent was removed in vacuo to give 8-chlorooctyl-2-furancarboxylate (9.7 g) (94%) as an oil.

Provenance & Evidence