HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 4,4'-Dihydroxy-3-biphenylcarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 4-Hydroxy-4′-methoxy[1,1′-biphenyl]-3-carboxylic acid | HCID 5197133 | — |
| Catalyst | Tetrabutylphosphonium bromide | HCID 76564 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4,4'-Dihydroxy-3-biphenylcarboxylic acid | HCID 23448412 | 48.3% |
Reaction Steps
A solution of 4-hydroxy-4′-methoxy-3-biphenylcarboxylic acid (5.3 g; 21.6 mmol), tetrabutylphosphonium bromide (0.8 g; 2.3 mmol), acetic acid (35 ml) and hydrobromic acid (35 ml of a 48% solution) was heated at reflux for 6 h. The reaction mixture was cooled and poured into water (400 ml). The resulting precipitate was isolated and recrystallised from ethyl acetate to give 2.4 g (47%) of 4,4′-dihydroxy-3-biphenyl-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06676851B1 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-a8468112a53940b59cdcc25b28d54e59 |
| Source note | uspto-grants-2004_01 |