Ethyl trifluoroacetate → HCID 20598898, compound

HRID 1838790Notes

Reaction equation

HRID 1838790 reaction equation
[CH2:1]([O:8][C:9](=[O:17])[CH2:10][CH2:11][C@@H:12]([C:14]([OH:16])=[O:15])[NH2:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O:20][C:21](=O)[C:22]([F:25])([F:24])[F:23])C>C(O)C>[CH2:1]([O:8][C:9](=[O:17])[CH2:10][CH2:11][C@@H:12]([C:14]([OH:16])=[O:15])[NH:13][C:21](=[O:20])[C:22]([F:25])([F:24])[F:23])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 9794Ethyl trifluoroacetateHCID 122337L-Glutamic acid, 5-(phenylmethyl) ester

Product 1

HCID 20598898HCID 20598898, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

100 g (421.5 mmol) of L-glutamic Acid-5-benzyl ester is dissolved in a mixture that consists of 1000 ml of trifluoroacetic acid ethyl ester/500 ml of ethanol, and it is stirred for 24 hours at room temperature. It is evaporated to the dry state, and the residue is crystallized from diisopropyl ether.

Workup

  1. customIt is evaporated to the dry state
  2. customthe residue is crystallized from diisopropyl ether

Sources & evidence

ORD record
ord-31ab69e411064465bd63fd8421a3267d
Source dataset
uspto-grants-2004_01
Patent number
US06676928B2

Reaction notes

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