Phenol → HCID 12109652, compound

Participants

Reaction Steps

To a solution of phenol (0.66 g, 7.08 mmol) in THF (5 mL) is added NaH (0.24 g, 5.91 mmol) followed by a solution of the crude 4-(4-fluorophenyl)-5-(2-methanesulfonylpyrimidin-4-yl)-1,2-dihydro-pyrazol-3-one, 5, prepared herein above (0.22 g, 0.67 mmol) in THF (2 mL). The reaction mixture is stirred for 1.5 hours at room temperature, diluted with aqueous NaHCO3 and extracted with twice with ethyl acetate. The organic layers are combined, dried over MgSO4, and concentrated in vacuo to afford the crude product which is purified over silica (100% EtOAc, followed by 10% MeOH/EtOAc) to provide the desired product as a yellow solid.

Provenance & Evidence