HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 11beta-Fluoro-3-methoxyoestra-3,5-dien-17-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | 11beta-Fluorooestr-4-ene-3,17-dione | HCID 10979145 | — |
| Solvent | 2,2-Dimethoxypropane | HCID 6495 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 11beta-Fluoro-3-methoxyoestra-3,5-dien-17-one | HCID 11738260 | — |
Reaction Steps
7.8 g of 11β-fluorooestr-4-ene-3,17-dione are stirred at 80° C. for 5 h with 780 mg of pyridinium toluene-4-sulphonate in 40 ml of 2,2-dimethoxypropane. 1.5 ml of triethylamine are then added, and the mixture is diluted with ethyl acetate and washed with saturated sodium chloride solution. After crystallization from methanol, 5.3 g of 11β-fluoro-3-methoxyoestra-3,5-dien-17-one of melting point 173° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06677324B1 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-91724e06c5b2454d9b1ec07d11205bdd |
| Source note | uspto-grants-2004_01 |