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HRID1838885

反应详情

EQUATION

反应方程式

HRID 1838885 的结构方程式

REACTANTS

反应物

3
结构：O
HCID962

Water

H2O

结构：CNCCCSCCCC(F)(F)C(F)(F)F
HCID11391445

未命名化合物

结构：Cc1ccc(S(=O)(=O)OCCCCC[C@@H]2Cc3cc(OC4CCCCO4)ccc3[C@@H]3[C@@H]2[C@@H]2CCC(=O)[C@@]2(C)C[C@@H]3F)cc1
HCID22941779

未命名化合物

PRODUCTS

生成物

1
结构：CN(CCCCC[C@@H]1Cc2cc(OC3CCCCO3)ccc2[C@@H]2[C@@H]1[C@@H]1CCC(=O)[C@@]1(C)C[C@@H]2F)CCCSCCCC(F)(F)C(F)(F)F
HCID15870676

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

2.0 g of 11β-fluoro-3-(tetrahydropyran-2-yloxy)-7α-(5-p-toluenesulphonyloxypentyl)oestra-1,3,5(10)-trien-17-one in 44 ml of DMF are stirred at 80° C. with 1.2 g of methyl-[3-(4,4,5,5,5-pentafluoropentylthio)propyl]-amine. After 6.5 h, the reaction mixture is treated with water. The mixture is extracted with ethyl acetate, washed with saturated sodium chloride solution and concentrated in vacuo. After chromatographing the crude product on silica gel using a methylene chloride-methanol gradient, 1.3 g of 11-fluoro-7α-{5-[N-methyl-N-3-(4,4,5,5,5-pentafluoropentylthio)propylamino]-pentyl}-3-(tetrahydropyran-2-yloxy)oestra-1,3,5(10)-trien-17-one are obtained as an oil.

WORKUP

后处理

  1. extractionThe mixture is extracted with ethyl acetate
  2. washwashed with saturated sodium chloride solution
  3. concentrationconcentrated in vacuo
  4. customare obtained as an oil