反应详情

89 mg of 11β-fluoro-3-hydroxy-7α-{6-[methyl-(8,8,9,9,9-pentafluorononyl)amino]hexyl}oestra-1,3,5(10)-trien-17-one are dissolved in 2 ml of ethanol and treated with 22 mg of sodium borohydride. After stirring at room temperature for 1 hour, the solvent is for the most part stripped off in vacuo, the residue is treated with sodium chloride solution, and the mixture is extracted 3 times with methylene chloride, dried over magnesium sulphate and concentrated in vacuo. Preparative thin-layer chromatography using methylene chloride/methanol=9/1 as an eluent leads to 53 mg of 11β-fluoro-7x-{5-[methyl-(8,8,9,9,9-pentafluorononyl)amino]hexyl}oestra-1,3,5(10)-triene-3,17β-diol are obtained as a foam, [α]D=+32° (c=1.0 in chloroform).

1. extractionthe mixture is extracted 3 times with methylene chloride
2. dry with materialdried over magnesium sulphate
3. concentrationconcentrated in vacuo
4. customare obtained as a foam, [α]D=+32° (c=1.0 in chloroform)