Sodium Chloride → HCID 69918825, compound

Participants

Reaction Conditions

Reaction Steps

660 mg of 7α-(5-bromopentyl)-11β-fluorooestra-1,3,5(10)-triene-3,17β-diol are dissolved in 10 ml of N-methylpyrrolidone, treated with 1.2 g of methyl-(2-p-tolylethyl)amine and stirred at a bath temperature of 80° C. for 3 hours. For work-up, the mixture is added to saturated sodium chloride solution, extracted with ethyl acetate, dried over sodium sulphate and concentrated to dryness in vacuo. Column-chromatographic purification on silica gel using an ethyl acetate-methanol-ammonia gradient and subsequent crystallization from ethyl acetate/methylene chloride/hexane yields 277 mg of 11β-fluoro-7α-{5-[methyl-(2-p-tolylethyl)amino]pentyl}oestra-1,3,5(10)-triene-3,17β-diol of melting point 142-143° C.

Provenance & Evidence