Cyclohexanemethanol → HCID 12986177, compound

Participants

Reaction Steps

Cyclohexylmethanol (10 ml) and sodium (5 eq; 0.163 g) were reacted at 90° C. for 1 h. 2-Amino-4-chloro-6dibenzylamino-5-pyrimidine carbaldehyde (0.5 g; 1.42 mmol) was added and heating continued for 90 mins. Excess alcohol was removed by short path distillation under reduced pressure, and the product purified further by column chromatography. Product was shown to be contaminated with cyclohexylmethanol by visualisation of the alcohol with sulfuric acid spray (2%).

Provenance & Evidence