HCID 54129137, compound → HCID 23450069, compound

HRID 1838971Notes

Reaction equation

HRID 1838971 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([CH:9]=[O:10])=[C:4]([N:11]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=2)[CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[N:3]=1.[CH3:30][Mg]Br>>[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([CH:9]([OH:10])[CH3:30])=[C:4]([N:11]([CH2:12][C:13]2[CH:14]=[CH:15][C:16]([O:19][CH3:20])=[CH:17][CH:18]=2)[CH2:21][C:22]2[CH:23]=[CH:24][C:25]([O:28][CH3:29])=[CH:26][CH:27]=2)[N:3]=1

Participants

3

Reactant 2

HCID 54129137HCID 54129137, compoundHCID 178418573HCID 178418573, compound

Product 1

HCID 23450069HCID 23450069, compound

Procedure

Procedure as above with 2-Amino-4-chloro-6-di(4-methoxybenzyl)amino-5-pyrimidine carbaldehyde (0.20 g; 0.48 mmol) and 3.0 M methyl magnesium bromide (3 eq; 0.5 ml). Product obtained as a colourless glass (0.159 g; 0.37 mmol; 77%).

Workup

  1. customProduct obtained as a colourless glass (0.159 g; 0.37 mmol; 77%)

Sources & evidence

ORD record
ord-06d36a2dd0ee41508e191d6f3dfa2f77
Source dataset
uspto-grants-2004_01
Patent number
US06677345B1

Reaction notes

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