5'-Bromo-2'-hydroxyacetophenone → HCID 22391975, compound

HRID 1839145Notes

Reaction equation

HRID 1839145 reaction equation
BrC1C=CC(O)=C(C(=O)C)C=1.Br[C:13]1[CH:14]=[N:15][CH:16]=[C:17]([CH:23]=1)[C:18]([O:20][CH2:21][CH3:22])=[O:19].[CH:24]([NH:27][C:28]([C:30]1[C:39](=[O:40])[C:38]2[C:33](=[N:34][CH:35]=[CH:36][CH:37]=2)[N:32]([C:41]2[CH:46]=[CH:45][CH:44]=[C:43](Br)[CH:42]=2)[CH:31]=1)=[O:29])([CH3:26])[CH3:25]>>[CH:24]([NH:27][C:28]([C:30]1[C:39](=[O:40])[C:38]2[C:33](=[N:34][CH:35]=[CH:36][CH:37]=2)[N:32]([C:41]2[CH:42]=[CH:43][CH:44]=[C:45]([C:13]3[CH:14]=[N:15][CH:16]=[C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:23]=3)[CH:46]=2)[CH:31]=1)=[O:29])([CH3:26])[CH3:25]

Participants

4

Reactant 3

HCID 959915'-Bromo-2'-hydroxyacetophenoneHCID 140785Ethyl 5-bromopyridine-3-carboxylateHCID 129913181-(3-bromophenyl)-N-isopropyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Product 1

HCID 22391975HCID 22391975, compound

Procedure

Following the procedure of Example 23 but substituting N-isopropyl-1-(3-bromophenyl)-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide for 5′-bromo-2′-hydroxyacetophenone and ethyl 5-bromonicotinate for N-isopropyl-1-(3-bromophenyl)-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide the title compound was obtained as a beige solid.

Sources & evidence

ORD record
ord-eac20f5fe7fa41d7aeada68f7c23ab69
Source dataset
uspto-grants-2004_01
Patent number
US06677351B2

Reaction notes

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