3-Acetylphenylboronic acid → HCID 22391970, compound

HRID 1839160Notes

Reaction equation

HRID 1839160 reaction equation
C(C1C=C(B(O)O)C=CC=1)(=O)C.Br[C:14]1[CH:15]=[CH:16][C:17]([C:20]([OH:23])([CH3:22])[CH3:21])=[N:18][CH:19]=1.C(NC(C1C(=O)C2C(=NC=CC=2)[N:32]([C:41]2[CH:46]=[CH:45][CH:44]=[C:43](Br)[CH:42]=2)C=1)=O)(C)C>>[NH2:32][C:41]1[CH:42]=[C:43]([C:14]2[CH:15]=[CH:16][C:17]([C:20]([OH:23])([CH3:22])[CH3:21])=[N:18][CH:19]=2)[CH:44]=[CH:45][CH:46]=1

Participants

4

Reactant 3

HCID 27343103-Acetylphenylboronic acidHCID 129913181-(3-bromophenyl)-N-isopropyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamideHCID 154863922-(5-Bromopyridin-2-yl)propan-2-ol

Product 1

HCID 22391970HCID 22391970, compound

Procedure

Following the procedure of Step 5 of Example 1, but substituting 3-aminophenylboronic acid for 3-acetyl phenylboronic acid and 5-bromo-2-(1-hydroxy-1-methylethyl)pyridine from Step 1 of Example 30 for N-isopropyl-1-(3-bromophenyl)-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide, the 5-(3-Aminophenyl)-2-(1-hydroxy-1-methylethyl) pyridine compound was obtained as a solid.

Sources & evidence

ORD record
ord-0272949210a64bc3a2ec719a64d8d88b
Source dataset
uspto-grants-2004_01
Patent number
US06677351B2

Reaction notes

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