HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1839171Generated: October 26, 2026
Sulfuric Acid → 5-Bromo-2-(1-methylvinyl)pyridine N-oxide
https://huagongshe.com/reaction/1839171
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-bromo-2-(1-hydroxy-1-methylethyl)pyridine N-oxide | HCID 22714291 | — |
| Product | 5-Bromo-2-(1-methylvinyl)pyridine N-oxide | HCID 69412377 | — |
Reaction Steps
A mixture of 5-bromo-2-(1-hydroxy-1-methylethyl) pyridine N-oxide from step 2 of example 30 (1.29 g) and 25% aqueous sulfuric acid was heated at 130° C. for 2 days. After cooling, the mixture was made slightly basic using ION aqueous sodium hydroxide and partitioned between ethyl acetate and water. The crude product from evaporation of the organic phase was used as such in step 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06677351B2 |
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| Source dataset | uspto-grants-2004_01 |
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| ORD ID | ord-5c92529410d94148be3bca85d3caf12b |
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| Source note | uspto-grants-2004_01 |
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