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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1839272Generated: November 2, 2026

Tert-Butylamine → HCID 86588189, compound

https://huagongshe.com/reaction/1839272

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTert-ButylamineHCID 6385—
ReactantHCID 18336823HCID 18336823—
SolventMethanolHCID 887—
ProductHCID 86588189HCID 8658818977.3%

Reaction Steps

To (2R,3R,4R,5S)4-(acetyloxy)-5-{3-[(acetyloxy)methyl]isoxazol-5-yl}-2-[2-chloro-6-(4-chloro-2-fluoroanilino)-9H-purin-9-yl]tetrahydrofuran-3-yl acetate (4.02 mg) in methanol (2 ml) at 0° C. was added tert-butylamine (0.012 ml), and the mixture was allowed to stand at 0° C. for 3 h. The solvent was evaporated in vacuo to furnish the title compound as a yellow gum (2.48 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06677316B2
Source datasetuspto-grants-2004_01
ORD IDord-303a17c4f88f4025891452220c346613
Source noteuspto-grants-2004_01