Thionyl Chloride → 2,6-Dichloro-4-(trifluoromethyl)nicotinoyl chloride

HRID 1839357노트

반응식

HRID 1839357 반응식
[Cl:1][C:2]1[N:10]=[C:9]([Cl:11])[CH:8]=[C:7]([C:12]([F:15])([F:14])[F:13])[C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:18])=O>>[Cl:1][C:2]1[N:10]=[C:9]([Cl:11])[CH:8]=[C:7]([C:12]([F:15])([F:14])[F:13])[C:3]=1[C:4]([Cl:18])=[O:5]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 219481962,6-Dichloro-4-(trifluoromethyl)nicotinic acid

생성물 1

HCID 219482122,6-Dichloro-4-(trifluoromethyl)nicotinoyl chloride

실험 절차

A solution of 2,6-dichloro-4-(trifluoromethyl)nicotinic acid (3.22 g, 13.2 mmol) in thionyl chloride (9 mL) was heated at reflux for 3 h. After cooling, the solution was concentrated in vacuo to give 2,6-dichloro-4-(trifluoromethyl)nicotinoyl chloride as a yellow oil which was carried on to the next step without further purification. This transformation can also be accomplished using oxalyl chloride with catalytic DMF in place of thionyl chloride.

후처리

  1. temperatureat reflux for 3 h
  2. temperatureAfter cooling
  3. concentrationthe solution was concentrated in vacuo

출처 및 근거

ORD 기록
ord-b94212989b69407fa6a1f53395161e41
출처 데이터셋
uspto-grants-2004_01
특허 번호
US06677352B1

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