4-(1-(4-fluorobenzyl)-1H-benzoimidazol-2-yl)-4-hydroxypiperidine → N-Methyl-N-(4-(4-(1-(4-fluorobenzyl)-1H-benzoimidazol-2-yl)-4-hydroxypiperidin-1-yl)-2-(4-methoxyphenyl)butyl)benzamide

HRID 183938Notes

Reaction equation

HRID 183938 reaction equation
[CH3:1][N:2]([C:3]([c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)=[O:10])[CH2:11][CH:12]([CH2:13][CH2:14][S:15]([CH3:16])(=[O:17])=[O:18])[c:19]1[cH:20][cH:21][c:22]([O:25][CH3:26])[cH:23][cH:24]1.[F:27][c:28]1[cH:29][cH:30][c:31]([CH2:32][n:33]2[c:34]([C:42]3([OH:48])[CH2:43][CH2:44][NH:45][CH2:46][CH2:47]3)[n:35][c:36]3[c:37]2[cH:38][cH:39][cH:40][cH:41]3)[cH:49][cH:50]1>>[CH3:1][N:2]([C:3]([c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)=[O:10])[CH2:11][CH:12]([CH2:13][CH2:14][N:45]1[CH2:44][CH2:43][C:42]([c:34]2[n:33]([CH2:32][c:31]3[cH:30][cH:29][c:28]([F:27])[cH:50][cH:49]3)[c:37]3[c:36]([n:35]2)[cH:41][cH:40][cH:39][cH:38]3)([OH:48])[CH2:47][CH2:46]1)[c:19]1[cH:20][cH:21][c:22]([O:25][CH3:26])[cH:23][cH:24]1

Participants

3

Reactant 2

HCID 155428854-(1-(4-fluorobenzyl)-1H-benzoimidazol-2-yl)-4-hydroxypiperidineHCID 18354479N-methyl-N-(2-(4-methoxyphenyl)-4-methanesulfonylbutyl)benzamide

Product 1

HCID 15870531N-Methyl-N-(4-(4-(1-(4-fluorobenzyl)-1H-benzoimidazol-2-yl)-4-hydroxypiperidin-1-yl)-2-(4-methoxyphenyl)butyl)benzamide

Sources & evidence

ORD record
ord-2326ce8ebc234c5f8564f537c6dce54e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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