2-Aminophenol → HCID 23450317, compound

HRID 1839467Notes

Reaction equation

HRID 1839467 reaction equation
[OH:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:9](Cl)(=[O:18])[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1.[C:20]([C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH2:25]Br)#[N:21]>>[C:20]([C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH2:25][O:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:9](=[O:18])[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)#[N:21]

Participants

4

Reactant 3

HCID 58012-AminophenolHCID 7477p-Anisoyl chlorideHCID 97249Benzonitrile, 3-(bromomethyl)-

Product 1

HCID 23450317HCID 23450317, compound

Procedure

Using a procedure similar to Example 33A and 33B except starting from 2-hydroxyaniline, p-anisoyl chloride and 3-cyanobenzyl bromide, the title compound was obtained as a solid (700 mg, 48%); MS.(FD): 358.1.

Sources & evidence

ORD record
ord-7e6d84a70fa54ef193d5b22abe9bf39f
Source dataset
uspto-grants-2004_01
Patent number
US06677369B2

Reaction notes

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