HRID1839501

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1ccc(S(=O)(=O)N[C@@H](CC(N)=O)C(=O)O)cc1

HCID6995570

未命名化合物

结构：Cc1ccc(S(=O)(=O)N(CC(C)C)[C@@H](CCCCN)C(=O)O)cc1

HCID23552860

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(S(=O)(=O)N[C@@H](CC(N)=O)C(=O)NCCCC[C@@H](C(=O)O)N(CC(C)C)S(=O)(=O)c2ccc(C)cc2)cc1

HCID508584

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from Nα-isobutyl-Nα-(4-methylbenzenesulfonyl)-L-lysine (100 mg, 0.29 mmol, example 1, step E) as described in general procedure Bc using Nα-(4-methylbenzenesulfonyl)-L-asparagine (90 mg, 0.3 mmol) which was prepared in step A of example 47. The final product was triturated with ether to yield 95 mg (15%) of the desired material.

WORKUP

后处理

customwas prepared in step A of example 47
customThe final product was triturated with ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ea565a88e24249eb95e8cd300c254c14
来源数据集: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06677367B2
来源说明: uspto-grants-2004_01

反应 SMILES

[CH2:1]([N:5]([S:15]([C:18]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=1)(=[O:17])=[O:16])[C@H:6]([C:12]([OH:14])=[O:13])[CH2:7][CH2:8][CH2:9][CH2:10][NH2:11])[CH:2]([CH3:4])[CH3:3].[CH3:25][C:26]1[CH:31]=[CH:30][C:29]([S:32]([NH:35][C@H:36]([C:41](O)=[O:42])[CH2:37][C:38](=[O:40])[NH2:39])(=[O:34])=[O:33])=[CH:28][CH:27]=1>>[CH3:25][C:26]1[CH:31]=[CH:30][C:29]([S:32]([NH:35][C@H:36]([C:41]([NH:11][CH2:10][CH2:9][CH2:8][CH2:7][C@H:6]([N:5]([S:15]([C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=2)(=[O:17])=[O:16])[CH2:1][CH:2]([CH3:3])[CH3:4])[C:12]([OH:14])=[O:13])=[O:42])[CH2:37][C:38]([NH2:39])=[O:40])(=[O:33])=[O:34])=[CH:28][CH:27]=1