N,N-Diethylethylenediamine → 2-formyl-5-methyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)-amide

HRID 1839650Notes

Reaction equation

HRID 1839650 reaction equation
[CH:1]([C:3]1[NH:4][C:5]([CH3:11])=[CH:6][C:7]=1[C:8]([OH:10])=O)=[O:2].[CH2:12]([N:14]([CH2:18][CH3:19])[CH2:15][CH2:16][NH2:17])[CH3:13]>>[CH2:12]([N:14]([CH2:18][CH3:19])[CH2:15][CH2:16][NH:17][C:8]([C:7]1[CH:6]=[C:5]([CH3:11])[NH:4][C:3]=1[CH:1]=[O:2])=[O:10])[CH3:13]

Participants

3

Reactant 2

HCID 60993N,N-DiethylethylenediamineHCID 219155882-formyl-5-methyl-1H-pyrrole-3-carboxylic acid

Product 1

HCID 207617692-formyl-5-methyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)-amideYield 94.4%

Procedure

2-Formyl-5-methyl-1H-pyrrole-3-carboxylic acid (3.0 g, 19.6 mmol) reacted with N,N-diethylethylenediamine (3.03 mL, 21.5 mmol) to give 2-formyl-5-methyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide (4.65 g, 94%).

Sources & evidence

ORD record
ord-80b4dd7767b6423c974b001e5de370c5
Source dataset
uspto-grants-2004_01
Patent number
US06677368B2

Reaction notes

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