2-formyl-5-methyl-1H-pyrrole-3-carboxylic acid → 2-formyl-5-methyl-1H-pyrrole-3 carboxylic acid (2-[1,2,3]triazol-1-yl-ethyl)-amide

HRID 1839652Notes

Reaction equation

HRID 1839652 reaction equation
[CH:1]([C:3]1[NH:4][C:5]([CH3:11])=[CH:6][C:7]=1[C:8]([OH:10])=O)=[O:2].[N:12]1([CH2:17][CH2:18][NH2:19])[CH:16]=[CH:15][N:14]=[N:13]1>>[N:12]1([CH2:17][CH2:18][NH:19][C:8]([C:7]2[CH:6]=[C:5]([CH3:11])[NH:4][C:3]=2[CH:1]=[O:2])=[O:10])[CH:16]=[CH:15][N:14]=[N:13]1

Participants

3

Reactant 2

HCID 219155882-formyl-5-methyl-1H-pyrrole-3-carboxylic acidHCID 225619722-(1H-1,2,3-Triazol-1-yl)ethanamine

Product 1

HCID 207616192-formyl-5-methyl-1H-pyrrole-3 carboxylic acid (2-[1,2,3]triazol-1-yl-ethyl)-amideYield 79%

Procedure

2-Formyl-5-methyl-1H-pyrrole-3-carboxylic acid (2.0 g, 13.06 mmol) reacted with 2-[1,2,3]triazol-1-yl-ethylamine (1.76 g, 15.67 mmol) to give 2-formyl-5-methyl-1H-pyrrole-3-carboxylic acid (2-[1,2,3]triazol-1-yl-ethyl)-amide (2.55 g, 79%).

Sources & evidence

ORD record
ord-4f15b8ff7f414583b640b953535b5155
Source dataset
uspto-grants-2004_01
Patent number
US06677368B2

Reaction notes

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