HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3R)-(+)-3-(Dimethylamino)pyrrolidine → 3-[(3R)-3-dimethylamino-pyrrolidin-1-ylcarbonyl]-5-methyl-1H-pyrrole-2-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3R)-(+)-3-(Dimethylamino)pyrrolidine | HCID 2758521 | — |
| Reactant | 2-formyl-5-methyl-1H-pyrrole-3-carboxylic acid | HCID 21915588 | — |
| Product | 3-[(3R)-3-dimethylamino-pyrrolidin-1-ylcarbonyl]-5-methyl-1H-pyrrole-2-carbaldehyde | HCID 20611466 | 69% |
Reaction Steps
2-Formyl-5-methyl-1H-pyrrole-3-carboxylic acid (536 mg, 3.50 mmol) reacted with (3R)-(+)-3-dimethylamino-pyrrolidine (480 mg, 4.20 mmol) to give 3-[(3R)-3-dimethylamino-pyrrolidine-1-carbonyl]-5-methyl-1H-pyrrole-2-carbaldehyde (600 mg, 69%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06677368B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-abcf7192a711482fa3f5a699c96cf211 |
| Source note | uspto-grants-2004_01 |