Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 4-(3-Piperidin-1-yl-propionyl)-1,4,5,6,7,8-hexahydro-pyrrolo[3,2-b]azepine-2-carbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 3-piperidin-1-yl-1-(5,6,7,8-tetrahydro-1H-pyrrolo[3,2-b]azepin-4-yl)-propan-1-one | HCID 22561894 | — |
| 생성물 | 4-(3-Piperidin-1-yl-propionyl)-1,4,5,6,7,8-hexahydro-pyrrolo[3,2-b]azepine-2-carbaldehyde | HCID 22561698 | — |
반응 단계
3-Piperidin-1-yl-1-(5,6,7,8-tetrahydro-1H-pyrrolo[3,2-b]azepin-4-yl)-propan-1-one (225 mg, 0.8 mmol) was formylated with POCl3 (91 μL, 1.2 eq.) and DMF(1 mL) using standard Vilsmierer condition to give 96 mg of 4-(3-piperidin-1-yl-propioyl)-1,4,5,6,7,8-hexahydro-pyrrolo[3,2-b]azepine-2-carbaldehyde as a light yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06677368B2 |
| 출처 데이터셋 | uspto-grants-2004_01 |
| ORD ID | ord-6d5f6e63ae44485fae1ef94ce29785e5 |
| 출처 메모 | uspto-grants-2004_01 |