Hydrochloric Acid → HCID 23450780, compound

Participants

Reaction Steps

A 1.2 M solution of lithium hydroxide (100pL, 0.12 mmol) was added to a solution of [4-(4-hydroxy-3,5-diiodobenzoyl)-2,6-diiodo-phenoxy]-acetic acid benzyl ester (prepared according to Example 10, 50 mg, 0.043 mmol) in 1 mL THF. The biphasic solution was stirred for 6 hours, after which time 1 M HCl was added. The resulting white precipitate was isolated by filtration, rinsed with water, and dried in vacuo, yielding the title compound as a white powder (42 mg, 94%). 1H NMR (400 MHz, DMSO-d6): δ 13.18 (br. s, 1H), 10.57 (br. s, 1H), 8.06 (s, 2H), 8.03 (s, 2H), 4.55 (s, 2H). HPLC (40-90), 12.41 min. LRMS (EI−) calc'd for [C15H8I4O5—H] 744.6, found 744.8.

Provenance & Evidence