1,2-Dibromo-4,5-difluorobenzene → 1-Bromo-4,5-difluoro-2-[4-(methylthio)phenyl]benzene

Participants

Reaction Steps

Following the general procedure outlined in Synthetic Scheme IV, 40 g (147 mmol) of 1,2-dibromo-4,5-difluorobenzene was reacted with 12.3 g (73 mmol) of 4-methylthiophenylboronic acid (Example 1, Step 2). Purification by silica gel chromatography with hexane gave 40.3 g of 1-bromo-4,5-difluoro-2-[4-(methylthio)phenyl]benzene as a yellow oil which was used without further purification.

Provenance & Evidence