(4-Chloro-3-methylphenyl)boronic acid → HCID 10572620, compound

Participants

Reaction Steps

Following the general procedure outlined in Synthetic Scheme VI, 1-bromo-4,5-difluoro-2-[4-(methylsulfonyl)phenyl]benzene (Example 18, Step 2) was reacted with 4-chloro-3-methylphenylboronic acid (Step 1) to give 4-(4-chloro-3-methylphenyl)-1,2-difluoro-5-[4-(methylsulfonyl)phenyl]benzene as a colorless solid: mp 151.5-152.2° C.; NMR (CDCl3) δ 2.29 (s, 3H), 3.05 (s, 3H), 6.73 (dd, J=2, 8 Hz, 1H), 6.98 (d, J=2 Hz, 2H), 7.16 (d, J=9 Hz, 1H), 7.19-7.32 (m, 4H), 7.82 (d, J=9 Hz, 2H); MS (FAB) m/z 399 (M+Li)+; HRMS calc'd for M+ 392.0449, found 392.0437. Anal. Calc'd for C20H15ClF2O2S: C, 61.15; H, 3.85; F, 9.67. Found: C, 61.04; H, 3.79; F, 9.55.

Provenance & Evidence