(4-Methoxy-3-methylphenyl)boronic acid → HCID 10739009, compound

Participants

Reaction Steps

Following the general procedure outlined in Synthetic Scheme VI, 1-bromo-4,5-difluoro-2-[4-(methylsulfonyl)phenyl]benzene (Example 18, Step 2) was reacted with 3-methyl-4-methoxyphenylboronic acid (Step 2) to give 1,2-difluoro-4-(4-methoxy-3-methylpheny)-5-[4-(methylsulfonyl)phenyl]benzene as a colorless solid: mp 160.5-161.5° C.; NMR (CDCl3) δ 2.11 (S, 3H), 3.04 (S, 3H), 3.79 (S, 3H), 6.63 (d, J=9 Hz, 1H), 6.74 (dd, J=2, 9 Hz, 1H), 6.85 (d, J=2 Hz, 1H), 7.15-7.27 (m, 3H), 7.30 (d, J=8 Hz, 1H), 7.80 (d, J=8 Hz, 2H); MS (FAB) m/z 395 (M+Li)+; HRMS calc'd for M+ 388.0945, found 388.0940. Anal. for C21H18F2O3S: C, 64.94; H, 4.67; F, 9.78. Found: C, 64.59; H, 4.84; F, 9.52.

Provenance & Evidence