3,5-Dichloro-4-methoxyphenylboronic acid → HCID 11797537, compound

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Reaction Steps

Following the general procedure outlined in Synthetic Scheme VI, 3,5-dichloro-4-methoxyphenylboronic acid (Step 2) was reacted with 4-(2-bromo-4,5-difluorophenyl]benzenesulfonamide (Step 3) to give 4-[2-(3,5-dichloro-4-methoxyphenyl)-4,5-difluorophenyl]benzenesulfonamide as a colorless solid: mp 145.5-146.0° C.; NMR (CDCl3) δ 3.89 (s, 3H), 4.78 (s, 2H), 6.98 (s, 2H), 7.18-7.29 (m, 4H), 7.85 (d, J=8 Hz, 2H); MS (FAB) m/z 450 (M+Li)+; HRMS calc'd for (M+H)+ 444.0039, found 444.0052. Anal. Calc'd for C19H13NCl2F2O3S: C, 51.37; H, 2.95; N, 3.15. Found: C, 51.59; H, 3.03; N, 3.15.

Provenance & Evidence