3,4-Dimethoxyphenylboronic acid → HCID 10668927, compound

Participants

Reaction Steps

Following the general procedure outlined in Synthetic Scheme VI, 1-bromo-4,5-difluoro-2-[4-(methylsulfonyl)phenyl]benzene (Example 18, Step 2) was reacted with 3,4-dimethoxyphenyboronic acid (step 1) to give 1,2-difluoro-4-(3,4-dimethoxypheny)-5-[4(methylsulfonyl)phenyl]benzene as a colorless solid: mp 140.0-141.0° C.; NMR (CDCl3) δ 3.04 (s, 3H), 3.61 (s, 3H), 3.86 (S, 3H), 6.48 (d, J=2 Hz, 1H), 6.65 (dd, J=2, 8 Hz, 1H), 6.75 (d, J=8 Hz, 1H), 7.17-7.29 (m, 2H), 7.31 (d, J=8 Hz, 2H), 7.81 (d, J=8 Hz, 2H); MS (FAB) m/z 411 (M+Li)+; HRMS calc'd for M+ 404.0894, found 404.0893. Anal. Calc'd for C21H18F2O4S (0.24 H2O): C, 61.70; H, 4.51. Found: C, 61.69; H, 4.56.

Provenance & Evidence