Potassium Carbonate → HCID 23451096, compound

Participants

Reaction Steps

Under nitrogen, 5 g (4.3 mmol) of Pd(PPh3)4 was added to a stirred solution of 7.9 g (17.8 mmol) of 1,2-dichloro-4,5-bis(trifluoromethanesulfonyl)benzene (Step 4), 3.0 g (18 mmol) of 4-methylthiophenylboronic acid (Example 1, Step 2) and 7.4 g (54 mmol) of anhydrous K2CO3 powder in 90 mL of toluene. The reaction was stirred at reflux for 48 hours, and diluted with CH2Cl2. The resulting solution was washed with water and brine, and dried over MgSO4. Purification by silica gel plug with ethyl acetate/hexane (5:95 to 30:70) gave 4.8 g (56%) of 1,2-dichloro-4-[4-(methylthio)phenyl]-5-(trifluoromethanesulfonyl)benzene as a colorless solid: NMR (CDCl3) δ 2.54 (s, 3H), 7.33 (s, 4H), 7.50 (S, 1H), 7.56 (S, 1H).

Provenance & Evidence