HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → N-Acetyl-D-Glucosamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | (3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol hydrochloride | HCID 2723635 | — |
| Reactant | HCID 178501943 | HCID 178501943 | — |
| Product | N-Acetyl-D-Glucosamine | HCID 439174 | — |
Reaction Steps
D-glucosamine hydrochloride (100 g, 0.46 mol) is added to a 0.6M solution of MeONa/MeOH and stirred for 5 minutes. Acetic anhydride (48 ml) is then added, and after 30 minutes a white precipitate appears, which is filtered and washed with cold ethanol. The liquor is recrystallised from absolute ethanol, obtaining 79.3 g of the compound (quantitative).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06680304B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-992cad5c097e4ba7baeffa70f898ef4e |
| Source note | uspto-grants-2004_01 |