2-Chloropropane → 5,6-bis(4-Methoxyphenyl)-4-cyano-2-isopropyl-2H-pyridazin-3-one

HRID 1840265Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:14]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)=[N:13][NH:12][C:11](=[O:23])[C:10]=2[C:24]#[N:25])=[CH:5][CH:4]=1.[CH:26](Cl)([CH3:28])[CH3:27]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:14]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)=[N:13][N:12]([CH:26]([CH3:28])[CH3:27])[C:11](=[O:23])[C:10]=2[C:24]#[N:25])=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 63612-Chloropropane

HCID 126885835,6-bis(4-methoxyphenyl)-4-cyano-2H-pyridazin-3-one

Product 1

HCID 155185045,6-bis(4-Methoxyphenyl)-4-cyano-2-isopropyl-2H-pyridazin-3-oneYield 72.6%

Procedure

Using 5,6-bis(4-methoxyphenyl)-4-cyano-2H-pyridazin-3-one and isopropyl chloride as starting materials, the procedures of Example 1 were repeated likewise, whereby the title compound was obtained in a yield of 72.6%.

Sources & evidence

ORD record: ord-61a3486eb17f45b79b253f910e20a00a
Source dataset: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06680316B1

Reaction notes

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