Hydrochloric Acid → 3-(4-Fluoro-phenyl)-isoxazole-4-carboxylic acid

Participants

Reaction Steps

A mixture of 0.79 g of Compound 8C, 3.5 mL of acetic acid and 3.05 mL of 37% HCl was refluxed for 4 h. After cooling to r.t., the solvent was evaporated to dryness at reduced pressure and the crude was taken up with 15 mL of water The precipitate was filtered off and dried to give 0.632 g (85.9%) of the title compound. M.p. 170-174° C.

Provenance & Evidence