HRID1840293

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID77521

4-Isoxazolecarboxylic acid, 3-(2,6-dichlorophenyl)-5-methyl-

C11H7Cl2NO3

HCID23447911

未命名化合物

PRODUCTS

生成物

结构：Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)NCCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1

HCID23447916

未命名化合物

收率 38%

PROCEDURE

实验过程

The title compound was synthesised according to the procedure described in Example 1, but using 3-(2,6-dichlorophenyl)-5-methylisoxazole-4-carboxylic acid instead of 3-phenyl-5-methyl-isoxazole-4-carboxylic acid and Compound 8B instead of Compound 1B. Extraction with diethyl ether followed by purification by flash chromatography (chloroform-2 N ammonia in methanol 100:3) afforded the title compound (38%) as an oil.

WORKUP

后处理

customThe title compound was synthesised
extractionExtraction with diethyl ether
customfollowed by purification by flash chromatography (chloroform-2 N ammonia in methanol 100:3)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7fee468c362744828e11f160e7525c70
来源数据集: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06680319B2
来源说明: uspto-grants-2004_01

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[C:13]([C:14]([OH:16])=O)=[C:12]([CH3:17])[O:11][N:10]=1.[NH2:18][CH2:19][CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][N:25]([C:28]2[CH:33]=[CH:32][C:31]([F:34])=[CH:30][C:29]=2[O:35][CH2:36][C:37]([F:40])([F:39])[F:38])[CH2:24][CH2:23]1>>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[C:9]1[C:13]([C:14]([NH:18][CH2:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][N:25]([C:28]3[CH:33]=[CH:32][C:31]([F:34])=[CH:30][C:29]=3[O:35][CH2:36][C:37]([F:38])([F:40])[F:39])[CH2:24][CH2:23]2)=[O:16])=[C:12]([CH3:17])[O:11][N:10]=1