反应详情

The title compound was synthesised according to the procedure described in Example 8 but using 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride instead of the crude 3-(4-fluorophenyl)isoxazole-4-carbonyl chloride and Compound 12B instead of Compound 8B. Washing the reaction mixture with 2 N sodium hydroxide, followed by the usual work-up and purification by flash chromatography (chloroform-2 N ammonia in methanol 100:3) afforded the title compound (92%) as an oil.

1. customThe title compound was synthesised
2. washWashing the reaction mixture with 2 N sodium hydroxide
3. customfollowed by the usual work-up and purification by flash chromatography (chloroform-2 N ammonia in methanol 100:3)